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According to a review conducted by the European Medicines Agency safety committee in 2025, non-arteritic anterior ischemic optic neuropathy is a very rare side effect of semaglutide that could affect 1 in 10,000 people 33

American Journal of Physiology-Endocrinology and Metabolism 2016;310:E744-E53

LC3-I is cytosolic, whereas LC3-II is membrane bound

Semaglutide does not appear on standard drug screening panels used for employment, legal, or clinical purposes