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Increased blood concentration of homocysteine is another nonspecific biomarker of vitamin B 12 deficiency that has been linked to depressive symptoms in the elderly (108)

Bioavailability the measure of how much of a substance actually enters your bloodstreamis the biggest hurdle

Deamer et al

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Musah BI, Wan P, Xu Y, Liang C, Peng L (2022) Contrastive analysis of nickel (II), iron (II), copper (II), and chromium (VI) removal using modified Chlorella vulgaris and Spirulina platensis : characterization and recovery studies