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Weeks 1-4: 0.25 mg per week (starting dose) Weeks 5-8: 0.5 mg per week Weeks 9-12: 1.0 mg per week Weeks 13-16: 1.7 mg per week Week 17 onward: 2.4 mg per week (regular dose) The slow increase helps with side effects

Where appropriate, further investigation, such as testing glutathione status or DHFR genetic variants, may help explain why some individuals respond differently to folic acid and identify when alternative forms of folate may be beneficial

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This can happen if the patient is not mindful of their eating habits and takes in excess air along with their food or beverages

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