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Linear mixed-effects models were applied to manage random effects from biological variability across subjects and repeated measurements, incorporating fixed effects (treatment, time, and their interaction) and random effects (individual variability)

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This complex mechanism of action requires caution in the use of nonselective agonists when researching relevant diseases [261, 262]

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Deyla Duarte Carneiro Vilela: Writing of the manuscript or critical review of important intellectual content