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Each increment in BMI of 5 kg/m 2 greater than 22,525,0 kg/m 2 corresponds to a rise in overall mortality of 30% ( Obesity pathophysiology is multifactorial and involves social, psychological and behavioral factors, genetic and metabolic predisposition (5)

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Additional research is needed to fully understand the implication of this mechanism in the regulation of GH secretion in somatotrophs cells along vertebrates

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However, if the animals are maintained on chow, Ex-4 injections into the VTA, NAc core, or shell does not suppress food intake, suggesting a role of GLP-1 signaling in motivation to feed [31]

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