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To interrogate the relative importance of consensus structure interactions for receptor binding and activation, we employed receptor mutagenesis, where each residue within the TMD that formed an interaction with any of the four peptides in the static cryo-EM structures was mutated to alanine (with the exception of A368 6 .57 , which was mutated to glycine), and the binding affinity and cAMP signalling of each peptide was assessed
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Kwizer et al [7] have examined the effects of hepatotoxic drugs such as paracetamol, cocaine, dextropropoxyphene and hycanthone on glutathione content of isolated rat hepatocytes and reported that addition of a hepatotoxic drug caused a rapid fall in glutathione content
The results demonstrated that the removal efficiency of 1 mol/L AMT could reach 98.5% of the 2.0 mg/L chlorine and UV treated for 30 min