Pregnant and lactating women, immune-compromised patients and those who have chronic serious health disorders may not be good candidates for this treatment
MHRA Updated semaglutide guidance including NAION warning (GOV.UK, February 2026) 10
Skin exam A baseline full-skin exam with a dermatologist before starting is the most useful single safety step, especially for anyone with many moles or fair skin
Sources Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial (2024) Journal of the American Medical Association [Accessed 2 December 2025] Dosing Schedule | Ozempic (semaglutide) (2025) [Accessed 2 December 2025] GIP and GLP1, the two incretin hormones: Similarities and differences (2010) Journal of Diabetes Investigation [Accessed 2 December 2025] Once-Weekly Semaglutide in Adults with Overweight or Obesity (2021) New England Journal of Medicine [Accessed 2 December 2025]
Some clinicians allow a shorter stay at the 1-2mg levels for patients transitioning from other GLP-1 agonists, since the GI adaptation to GLP-1 activation carries over somewhat
With tech already deployed in warzones, a $50M U.S
