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In this chapter, we briefly review some aspects of the biology and physiology of oral melanocytes, the function of melanin in the oral epithelium, and the features of several different oral mucosal melanin hyperpigmentations, including physiological hyperpigmentation, tobacco-related melanosis, human immunodeficiency virus (HIV)-associated melanosis, melanotic maculae, naevomelanocytic naevus, and oral mucosal melanoma

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Over a 12-week study, the authors reported a mean weight loss of 1.9 kg, 2.8 kg and 2.4 kg with the use of 50 mg, 100 mg or 300 mg respectively [69]

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