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Adult-onset calorie restriction attenuates kainic acid excitotoxicity in the rat hippocampal slice
NAD+ levels decline with age : 40-year-old adults have ~50 % of the NAD+ levels of 20-year-olds 60-year-old adults have ~25 % of younger NAD+ levels The decline is visible in all tissues , muscle, liver, brain, skin, blood The mechanism of decline is multifactorial : Increased CD38 activity , the enzyme that breaks NAD+ down
Additionally, miR-379-5p, which is downregulated in the bone marrow microenvironment, was found to inhibit AKR1C3, suggesting a novel miR-379-5p/AKR1C3/ERK signaling axis in imatinib resistance in CML (Pan et al., 2021)
It is unknown whether the core drivers of ferroptosisRF crosstalk (e.g., iron overload vs
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