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Ecnoglutide is a novel cAMP signaling-biased agonist that preferentially activates G protein pathways over beta-arrestin recruitment, which may reduce receptor desensitization and potentially improve long-term efficacy

Cancer 10 , e004232 (2022)

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Although several studies have stated that leptin can be an effective pharmaceutical tool for treating obesity in leptin-deficient states, the administration of exogenous leptin does not significantly decrease adiposity in the majority of instances of human obesity