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If left unmanaged, it can lead to: Bloating Gas Abdominal pain Hemorrhoids from straining Rectal discomfort or anal fissures And in rare cases, severe constipation can lead to impaction (where stool gets stuck in the colon and cant pass on its own)

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Obesity drives hyperinsulinemia and insulin resistance (IR), increasing risks of hyperglycemia, HTN, dyslipidemia, CKD, inflammation, oxidative stress, and OSA [76]

Identifying cysteine, N-acetylcysteine, and glutathione conjugates as novel metabolites of aristolochic acid I: emergence of a new detoxification pathway

Calcium in the prevention of postmenopausal osteoporosis: EMAS clinical guide