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The prescribing information is explicit: Rybelsus must be taken on an empty stomach with no more than 120 ml of plain water, and patients must wait at least 30 minutes before eating, drinking, or taking other medications

When gynecomastia develops after starting a new medication, the benefits are weighed against the impact of breast enlargement before deciding on next steps

For instance, Retana et al

With GLP-1 prescriptions averaging around $1,000 per month, these medications now account for over 10% of total employer health plan claims in 2025, according to data cited by the International Foundation of Employee Benefit Plans (IFEBP)

However, oral or injected corticosteroids (like prednisone) can raise blood sugar levels

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