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Furthermore, H&E staining showed that compared to the aorta of normal aging mice, the aorta of mice treated with FOXO4-DRI was thinner, and the PWV value was lower in the ultrasound detection results, which means that the mice treated with FOXO4-DRI had better vascular elasticity and better vascular function than normal aging mice (Figures 1D,E)

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10.1038/s41598-021-01750-0 13 Perez-TilveD.Gonzlez-MatasL.AulingerB