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Despite its commendable safety and effectiveness, there are notable differences in glycemic response in individuals with metformin therapy (DeFronzo and Goodman, 1995), probably due to uncertainty in the pharmacokinetics and pharmacodynamics of metformin

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Langmuir 27, 9551 (2011).CrossRefGoogle ScholarPubMed Irmukhametova, G.S., Fraser, B.J., Keddie, J.L., Mun, G.A., and Khutoryanskiy, V.V.: Hydrogen-bonding-driven self-assembly of PEGylated organosilica nanoparticles with poly(acrylic acid) in aqueous solutions and in layer-by-layer deposition at solid surface

Headache and fatigue can occur, especially during dose increases