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30 Whereas IENF density and mtDNA copies/cell did not change after therapy, improvements in neuropathic pain, paresthesias, and symptoms of numbness were observed

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However, a 2003 systematic review highlighted differences in methodologies between early and later studies that make it difficult to compare results (104)

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1991 (landmark Italian trial): A double-blind, placebo-controlled trial involving 130 patients with Alzheimer's disease demonstrated that one year of ALCAR treatment resulted in a slower rate of deterioration compared to placebo across 13 of 14 outcome measures, including significant improvements in the Blessed Dementia Scale, logical intelligence, verbal critical abilities, long-term verbal memory, and selective attention [5][17]