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Taken together, our findings suggest that hydropersulfides (and/or other S 0 species derived from hydropersulfides) can act as direct oxidant scavengers already at low concentrations (as reflected by the suppression of H 2 O 2 -induced roGFP2-Orp1 or MitoPY1 oxidation), and additionally as inducers of protein hydropersulfidation, which however seems to require higher concentrations (as reflected by the induction of roGFP2 oxidation)

Figure 5: GHK and GHK-PEG induce apoptosis in SH-SY5Y cells

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