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Iron is also abundant in the brain and is involved in the formation of hydroxyl radicals (Valko et al., 2007)

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Advances in technology have led to significant improvements in CRC treatment, including endoscopic and surgical resection, radiotherapy, chemotherapy, surgery for metastatic colon cancer, local ablation, targeted drugs, and immunotherapy [252]

The hypoxia pathway is also highly related to the pathological mechanism of male infertility caused by varicocele