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For example, studies using radiolabeled exenatide have shown that it can readily enter the mouse brain, though this central uptake appears to diminish at higher doses (Kastin and Akerstrom, 2003)

That initial 0.5-1 kg gain reflects intracellular hydration, not new fat

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slowed gastric emptying (gastroparesis) GLP-1 agonists stimulate GLP-1 receptors in the CNS including vagal efferent fibers in the brainstem

This phenomenon, known as the incretin effect, is greatly reduced in diabetics, a difference that led to the development of analogues of incretin GLP-1 and GIP

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