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Amyloid- (A) plaques further exacerbate this process by generating ROS after entering mitochondria through the translocase of the outer membrane, causing mitochondrial dysfunction (Chen and Yan, 2007)

wustl.edu Cellular mechanisms to clear misfolded proteins, and therapies to minimize toxicity by stimulating degradation of misfolded proteins As a physician-scientist, David Perlmutter is internationally recognized for his research on alpha-1 antitrypsin deficiency (ATD), a genetic disorder in which accumulations of a misfolded protein can cause severe liver damage

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This enzyme is overactive in individuals with excess abdominal fat and metabolic dysfunction

Is there any good literature on the topic