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66 Human clinical studies remain limited to small, non-randomized, or retrospective case series, which cannot support definitive therapeutic claims.64

The efficiency of GSTM3 knockdown and GSTM3 overexpression compared to the NC cell lines were confirmed using qRT-PCR and western blot (Figures 2CE)

Conversely, in cancer, where autophagy is often upregulated to promote survival, inhibiting autophagy while simultaneously targeting the UPS could lead to the accumulation of toxic proteins and induce cell death

"The antidepressant effect of an antiulcer pentadecapeptide BPC 157 in Porsolt's test and chronic unpredictable stress in rats." Journal of Physiology Paris

GPx4 is unique as a monomer, exhibiting broad substrate specificity and subcellular distribution, and specializes in reducing lipid peroxides and protecting cellular membranes from peroxidative damage [3, 4]

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