For example, ailanthone blocks autophagy by upregulating growth arrest specific (GAS)5 via inhibition of up-frameshift protein 1-mediated nonsense-mediated mRNA decay, thereby inhibiting NSCLC proliferation (22)
Ching YP, Davies SP, Hardie DG (1996) Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA reductase, using a single primer variant of the unique-site-elimination method
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Translating animal research for human application is seldom uncomplicatedvariations in metabolism, immune response, and peptide absorption can markedly alter the compounds behavior in humans