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GI side effects (nausea, vomiting, constipation) correlate with the plasma peak, not with average exposure

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72% male) from 804 sites in 41 countries with overweight or obesity (BMI of 27 kg/m or higher) who were enrolled and treated with weekly injections of semaglutide (at doses slowly titrated to 2.4 mg at week 16) or placebo

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However, reduced side effects at lower doses make it likely there are also reduced therapeutic effects

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