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doi:10.1016/j.foodchem.2013.05.017

Thus, the endocannabinoids appear to negatively regulate basal and stimulated ACTH release at multiple levels of the hypothalamo-pituitary-adrenal axis

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Accumulation of PIP 3 attracts downstream effector proteins containing PH domains, including PDK1 and mTORC2 (also called PDK2), which phosphorylate Akt (PKB) at Ser308 and Thr473, respectively, leading to full activation of Akt (74, 76)

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