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Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer

This imbalance leads to the infiltration of M1 macrophages, forming CD11c+ crown-like structures (CLS) around dead cells in WAT, resulting in the accumulation of high amounts of lipids within macrophages and promoting inflammation [99, 101]

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However, in April 2022, the FDA published draft guidance indicating it was considering permitting NAC as a dietary supplement, noting that its initial safety review had not revealed concerns regarding supplemental use [6]

It is naturally found in animal products, including seafood, poultry, meat, eggs, and milk products