Key Takeaways Starting dose: 2.5 mg once weekly for 4 weeks Dose increases: 2.5 mg every 4 weeks until reaching target dose Maximum dose: 15 mg once weekly Alternative dosing: Split into 3 smaller doses (Monday, Wednesday, Friday) to reduce side effects Missed dose: Take as soon as possible if within 4 days
These reactions typically manifest as localized erythema (redness), pruritus (itching), swelling, or mild discomfort at the injection site
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NICE and Clinical Community Perspective According to Helen Knight, Director of Medicines Evaluation at NICE the clinical evidence demonstrates a meaningful reduction in recurrent cardiovascular events when semaglutide is added to standard therapy
Pharmacovigilance data shows very similar reporting odds ratios: 1.35 for tirzepatide versus 1.34 for semaglutide