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Overall, these studies indicate that glutamate may be unchanged or reduced, especially in more chronic cases, depending on the persistence of symptoms or other factors associated with long-term illness [29,30,31,32,33,34,35,36,37]
Abbreviations 5FU fluorouracil AMPK AMPactivated protein kinase BAK Bcl2 antagonist/killer 1 BAX Bcl2associated X protein Bcl2 Bcell lymphoma 2 BclxL Bcell lymphomaextra large CDC7 cell division cycle 7related protein kinase CHOP C/EBP homologous protein Mcl1 myeloid cell leukemia sequence 1 MRP1/7 multidrug resistanceassociated protein 1/7 mTOR mechanistic target of rapamycin PERK protein kinase RNAlike endoplasmic reticulum kinase SHMT serine hydroxymethyltransferase SOX2 SRYbox transcription factor 2 STAT3 signal transducer and activator of transcription 3 TCTP translationally controlled tumor protein TP53 tumor protein p53 1

Saghatelyan, T., Tananyan, A., Janoyan, N., Tadevosyan, A., Petrosyan, H., Hovhannisyan, A., Hayrapetyan, L., Arustamyan, M., Arnhold, J., Rotmann, A.R., Hovhannisyan, A., Panossian, A.: Efficacy and safety of curcumin in combination with paclitaxel in patients with advanced, metastatic breast cancer: a comparative, randomized, double-blind, placebo-controlled clinical trial
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Five studies of BPC-157 reviewed by the agency were of short duration, had small sample sizes and evaluated doses that were likely exploratory in nature, the staffers said