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These effects may stem from interactions between central GLP1 receptors and the serotonergic (5HT) system, where GLP1 receptor activation modulates 5HT neuronal activity, influencing proopiomelanocortin neurons implicated in mood regulation [2]

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N Engl J Med 373:232242 Scirica BM, Bhatt DL, Braunwald E et al (2013) Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus