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The caution around combining copper peptides and retinoids stems from two concerns

10.3389/fphys.2018.01939 [DOI] [PMC free article] [PubMed] [Google Scholar]

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The Biochemistry of GHK-Cu Degradation and Why Temperature Matters GHK-Cu (glycyl-L-histidyl-L-lysine bound to copper) is a tripeptide-copper complex with a molecular weight of 340 Dasmall enough to penetrate the stratum corneum but structurally fragile once formulated in aqueous or emulsion vehicles