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Inhibiting Gln metabolism can impair SERCA activity by reducing intracellular GSH levels, which may lead to the increased expression of PD-L1

doi: 10.1007/s40268-019-0273-0

Thus, truncation of the C-terminal L585 residue of the GLP-1 fusion containing WT albumin reduces its cellular recycling in vitro and plasma half-life in vivo, which may be compensated for by QMP engineering of albumin, irrespective of the presence of L585

Scientific Reports , 14 (1), 5002

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