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While the heme may have prooxidant functions in large quantities, heme is constantly turned over and excreted from cells as bilirubin [81]

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In one orientation, it is adjacent to the finger subdomain, whereas in the other orientation, it interacts with the RNA duplex, suggesting that nsp8 may have regulatory functions in replication initiation

However, consulting with a dermatologist is recommended to ensure compatibility and safety

McCormick & Bal, 1994)

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