For the once-weekly subcutaneous formulation, the SUSTAIN program (Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes) included 13 separate randomized clinical phase 3a and 3b trials (1013, 22, 2532) SUSTAIN 1 through 10 were global international trials, while three additional trials were specific for China and Japan
Important Limitations to Keep in Mind While promising, this research comes with important caveats: It still does not prove that semaglutide directly prevents dementia The findings apply only to people with Type 2 diabetes The exact mechanism of brain protection remains unclear For now, these results should be viewed as encouraging but not conclusive
Semaglutide Science While GLP-1 is a naturally occurring hormone, semaglutide is a synthetic version that helps with longer-lasting blood sugar stability
Medically reviewed by Alan Lucks | MD , Alan Lucks MDPC Private Practice - New York on January 17th, 2026
11.01.24 Warning label updated to include pulmonary aspiration The warning labels on Ozempic, Wegovy, Rybelsus, Saxenda, Victoza, Mounjaro and Zepbound were updated to include pulmonary aspiration during general anesthesia or deep sedation
Policy This loss of muscle can be managed with strategies like focusing on eating enough protein, engaging in strength training and slowly losing weight