Apart from reward, this initial AUD phase is influenced by the motivation to consume alcohol, which is another factor controlled by GLP-1R in male rats
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Cardiometabolic outcome trials Pooled analysis of Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) 1-5 (assessing semaglutide at lower doses of 0.5 and 1 mg doses for the treatment of T2D), found semaglutide had a similar weight reduction, and glycaemic control, efficacy in older and younger adults
(27) Additionally, GLP-1 agonists were linked to lower hospitalization rates, mortality, and a reduced risk of lower limb amputation (HR: 0.83, 95% CI: 0.671.03)