glp 1 and liver disease GLP-1 receptor agonists effective for obesity treatment Revolutionizing MASLD treatment with GLP-1

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The half-life of each GLP-1 analogues and strategies to prolong and enhance its efficacy Optimization of molecular structure The strategy of acylation with fatty acid has been applied for semaglutide and tirpatide, allowing these drugs to bind to human serum albumin (HSA)

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Regarding glucose-metabolism, two studies found that GLP-1(9-36), GLP-1 (7-36) and Liraglutide significantly inhibited insulin-stimulated glucose uptake [12, 13], with Liraglutide showing a dose dependent inhibition, with a maximum at a concentration of 1000 nM [12, 13]