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This molecule serves as a cofactor for enzymes in energy metabolism and participates in glycolysis, fatty acid oxidation, and the citric acid cycle

The discovery of the ubiquitinproteasome system (UPS) in the 1980s by Hershko, Ciechanover, and Rose revolutionized our understanding of intracellular protein degradation and enabled the development of proteasome-targeted cancer therapies

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They can also increase blood flow to reproductive organs