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Further analysis indicated that among the 19 overgrown bacterial families, 12 possessed the urease gene ( Alteromonadaceae , Clostridiaceae , Cellulomonadaceae , Enterobacteriaceae , Dermabacteraceae , Halomonadaceae , Micrococcaceae , Moraxellaceae , Methylococcaceae , Pseudomonadaceae , Polyangiaceae , and Xanthomonadaceae ), 5 harbored the uricase gene ( Dermabacteraceae , Cellulomonadaceae , Xanthomonadaceae , Micrococcaceae , and Polyangiaceae ) producing ammonia that is harmful to the intestinal epithelium, and 3 expressed the tryptophanase gene necessary for the conversion of tryptophan into indole, which is then metabolized by the liver into uremic toxins ( Enterobacteriaceae , Clostridiaceae , and Verrucomicrobiaceae ) (Wong et al., 2014)
Oral Berberine Ameliorates High-Fat Diet-Induced Obesity by Activating TAS2Rs in Tuft and Endocrine Cells in the Gut. Life Sciences, vol
10.1016/s0006-3223(98)00043-2 5 DahlD.OnishiY.NorwoodP.HuhR.BrayR.PatelH.et al (2022)
pounds A 510% reduction in body weight can mean different amounts of pounds
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