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3,4 In contrast, in Parkinson's disease (PD), neuronal deposits of -synuclein are present and form the primary structural component of Lewy body fibrils that are characteristic of the disorder, whereas in Huntington's disease (HD), cytoplasmic and nuclear deposition of the huntingtin protein and fragments thereof are found

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When I evaluate a patient, I still consider: A1C Fasting glucose Postprandial glucose Hypoglycemia risk Medication burden Nutrition patterns Exercise capacity Weight and body composition But I also consider: ASCVD risk Heart failure risk Chronic kidney disease Albuminuria Blood pressure Lipids Inflammatory load Sleep apnea risk Fatty liver risk Musculoskeletal limitations Neuropathy Autonomic dysfunction Patient goals and medication access This is why the ADA, ACC, AHA, and KDIGO now align more closely around comprehensive risk reduction

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Additionally, RB1 deficiency is able to enhance tumor metastasis by increasing OXPHOS to generate more ATP fueling for tumor invasion and cooperating oncogenic alterations to uphold EMT and metastasis (232)

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