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1 Introduction Erectile dysfunction (ED), defined as the inability to achieve and maintain an erection sufficient for sexual intercourse, is estimated to occur in 20% of men over the age of 40 and the incidence increases with age ( A recent retrospective cohort study suggested that GLP-1RAs might have induced positive vasculature effects, thereby improving erectile function in patients with T2D ( Mendelian randomization (MR) can generate more reliable evidence with less confounding and reverse causation by using genetic variants related to the exposure or drug target for causal inference and prediction of potential adverse outcomes for a specific drug target ( 2 Methods 2.1 Study design The drug target MR analysis was employed to investigate whether GLP-1RAs causally link to the risk of ED ( Figure 1 )

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11 Rather than combining two distinct moleculesone a GLP-1RAs and the other a GIP receptor agonistresearchers have engineered novel molecules by modifying the native amino acid sequence of GIP