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If metabolized too quickly drugs may be broken down and eliminated before they can take effect

Some patients may experience side effects such as nausea or digestive discomfort, which often subside as the body adjusts to the medication

None of the other coauthors have any competing interests to declare

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Stage two is initial physiological effects like appetite suppression and gastric slowing, which many people notice within 24 to 72 hours

Simulation of sprayed particle deposition in a human nasal cavity including a nasal spray device