If your calorie intake remains high despite a decreased appetite, or if you dont engage in enough exercise, you may not lose weight
Currently, many GLP-1RAs have already been approved for the treatment of diabetes and obesity and could be repurposed for the treatment of pain symptoms
In a 68-week placebo-controlled trial, once-weekly semaglutide (Ozempic, Wegovy) injections in people with obesity and moderate knee osteoarthritis produced significantly greater reductions in body weight along with significant improvements in pain scores and better physical function
In addition to weight loss benefits, GLP-1 therapy is an effective treatment for type 2 diabetes
GLP-1 signaling affects appetite and glucose regulation
A recent meta-analysis encompassing 11 observational and case-control studies across various countries revealed no statistically significant disparity in suicidal outcomes between GLP-1 RA users and those utilizing alternative antihyperglycemic medications (relative risk, 0.57
