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Brain Chemistry Changes That Support Recovery From Binge Eating Beyond physical fullness, GLP-1 medications alter dopamine signaling in the brain's reward centers

Sappl et al., 2009

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The reduction of PHB2 inhibits the binding of PHB2 to LC3, inhibits mitophagy, exacerbates the loss of dopaminergic neurons, and accelerates the progression of Parkinsons disease [16]

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Notably, ROS can react with unsaturated lipids to form lipid peroxides such as malondialdehyde, 4-hydroxy-2-nonenal (4-HNE), and acrolein, further exacerbating oxidative stress [30, 31]