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Timing the Switch Contrary to some beliefs, a lengthy washout period between stopping semaglutide and starting tirzepatide is generally not required
The mechanism is straightforward: GLP-1 RAs enhance glucose-dependent insulin secretion, and stacking that on top of glucose-independent insulin release from exogenous insulin or sulfonylureas removes the glucose-dependent safety brake
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Additionally, the emergence of deep reinforcement learning (DRL)which integrates deep learning with reinforcement learningcontinues to evolve, offering greater learning capacity and adaptability in dynamic environments [39]