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Research indicates that GPER expression is closely related to androgen levels, and patients with PCOS often present elevated androgen levels [157], which may lead to abnormal GPER function, thus affecting ovarian physiological functions and metabolic status [157]

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doi: 10.1146/annurev-nutr-071715-050947

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Yes, people with pernicious anemia need vitamin B12 for life

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In advanced cases of Hashimotos and primary hypothyroidism, this lab test will be elevated

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Briviba K, Fraser G, Sies H, Ketterer B (1993) Distribution of the monochlorobimane-glutathione conjugate between nucleus and cytosol in isolated hepatocytes

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However, several drugs have been used "off label," including pentoxifylline (PTX) and corticosteroids

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