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High iron levels are a risk factor for type 2 diabetes mellitus (T2DM) and impacts the cardinal features: such as increased insulin resistance, decreased insulin secretion and elevated hepatic gluconeogenesis

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No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate

Koo JE, Park ZY, Kim ND, Lee JY

The folate cycle is crucial for its role in the synthesis of S-adenosylmethionine (SAM) and the metabolism of vitamin B12 (, , , )

10.1038/s41598-020-80455-2 47 DengJ.GuoL.WuB