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doi:10.1001/archdermatol.2011.260

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Tirzepatide mimics both GLP-1 and GIP hormones, potentially offering greater weight loss than semaglutide alone

GLP-1, GIP, and Glucagon Receptors: Understanding Triple Agonism Retatrutide targets three hormonal receptors: GLP-1 (appetite suppression and insulin secretion), GIP (incretin and fat metabolism), and glucagon (energy expenditure and lipolysis)

Some clinicians speculate that improved endothelial healing could indirectly support erectile function, especially if vascular injury is present

All references verified against PubMed (10 July 2026)