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For context on adjacent metabolic research tools, the 5-Amino-1MQ Research Guide UK 2026: NNMT Inhibition & Metabolic Studies provides a complementary perspective on non-incretin metabolic pathways under active investigation

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Notably, compound 6 (Figure 9), a highly selective COX-2 inhibitor (IC 50 = 0.04 M, SI = 337.5), showed superior results in reducing ROS and NO production compared to celecoxib