NO signaling in the CNS: from the physiological to the pathological
Any cloudiness may indicate aggregation or microbial contamination Visible particles or floaters particulate matter suspended in the solution is a clear sign of degradation or contamination Discolouration yellowing or browning of the solution suggests oxidative degradation of amino acid residues Gel-like or viscous consistency peptide aggregation can occasionally produce a thickened solution Compromised vial or packaging integrity any damage to the vial, stopper, or seal is grounds for immediate discard Beyond visual inspection, time elapsed since reconstitution is itself a critical consideration
If the solution loses color (fades, turns greenish or colorless), the peptide has lost activity
(Avoid long-term storage at 4.2 V or below 3.5 V per cell) Inspect regularly for swelling or physical damage
Likewise, also important for multiple sclerosis therapy, natalizumab also carries a specific risk of progressive multifocal leucoencephalopathy and reactivation of JC virus infection (24)
[PMID 27797785] Lipase increases In trials, lipase increases occurred in 5.3% of Saxenda-treated patients and 2.2% of placebo-treated patients, with levels 3 X ULN occurring in 2.1% and 1%, respectively
