Common side effects associated with B12 supplementation include: Local injection site reactions (for intramuscular preparations): Pain, redness, or swelling at the injection site Mild bruising or tenderness Itching localised to the injection area These reactions are usually self-limiting and resolve within 2448 hours
This subcutaneous delivery method provides optimal bioavailability and consistent drug release
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(PubMed) Smith AD, Refsum H, Bottiglieri T, et al