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This subjective improvement could reflect placebo effect, improved overall nutritional status from paying more attention to diet, natural adaptation to the medication over time, or actual b12 repletion if deficiency existed

10.3390/antiox12030603 82 SabelliR.IorioE.De MartinoA.PodoF.RicciA.ViticchiG.et al (2008)

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Furthermore, GSH can modulate protein function via S-glutathionylation under oxidative stress

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In view of (a) the potentially similar metabolic effects of G6PD and GR deficiency, (b) the well documented protection from severe falciparum malaria afforded by G6PD deficiency [14], [19] and (c) the fact that P