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Zurek M, Aavik E, Mallick R, Yla-Herttuala S (2021) Epigenetic regulation of vascular smooth muscle cell phenotype switching in atherosclerotic artery remodeling: a mini-review

With reduced preload the heart does not have to exert as much contractile force which reduces the oxygen requirements of the heart and also reduces ventricular transmural pressure resulting in reduced compression of the coronary arteries allowing for more efficient blood flow through the heart

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Slides were mounted using Mowiol 4-88 (Merck) and images were acquired using an SP8 confocal microscope (Leica, Heidelberg, Germany) with a 63X oil objective, equipped with white-light laser