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The change was -2.7 [95% confidence interval (CI): -3.9, -1.5] in the mecobalamin 50 mg group and -4.6 [95% CI: -5.8, -3.4] in the placebo group, with a difference in change of 2.0 (95% CI: 0.4, 3.5
Prolonged deficiency can also cause irreversible damage to the nervous system, leading to neurological disorders
Thats where modern peptide therapy enters the conversation
doi: 10.1016/j.vph.2018.02.010
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